(Olivier, van Dalen and Hartog, 1986), maternal aggression (Yoshimura and Ogawa,ġ989) and isolation-induced aggression (Olivier et al, 1986 Miñarro,Ĭastaño, Brain and Simón, 1990 Navarro, Miñarro and Simón,ġ992). (Nakao, Higashio and Inuka, 1985), hypothalamic stimulation induced aggression Takeda, Kazahaya, Otsuki and Sandyk, 1988), electric-shock induced aggression The range of doses between 0.1 and 2.5 mg/kg) and a significant reduction inĪggressive behaviour has been described using different animal models: predatoryĪggression (Delini-Stula and Vassout, 1979), clonidine induced aggression (Fujiwara, Most of the relevant studies have focussed on its acute effects (with Haloperidol, like other neuroleptics, shows obvious antiaggressiveĮffects. Thus, brain levels were aIways considerably higher than those in serum (Zetler and Baumann, 1985). After these times, the drug levels in serum and brain decreased with a phase of rapid decline in the first 6 hours and a second slower phase of decline (12 hours approximately in serum, and between 12 and 24 hours in the brain). In the mouse brain the concentration of haloperidol rises during the first 30 minutes up to a 7-fold of its serum level. After subcutaneous administration of 0.6 mg/kg, the absorption of the drug was very fast so that after 2 minutes it had reached already its maximal serum concentration which began to decrease only after 15 minutes. Zetler and Bauman (1985) have studied the pharmacokinetics of haloperidol in the mouse serum and brain. In this study, the authors found that plasma levels of the drug were not detectable at times longer than 2 days after injection however, the half-live of haloperidol in the brain was many times greater (ca. Recently, Cohen, Tsuneizumi, Baldessarini, Campbell and Babb (1992) have determined the persistence of haloperidol (1 mg/kg ip) in rat plasma and brain tissue, using high pressure liquid cromatography. Typically quoted halflives for neuroleptics, including haloperidol, are approximately 24 hours or less (Baldessarini, 1990) however, there is suggestive evidence that elimination of haloperidol slows with time after dosing (Hubbard, Ganes and Midha, 1987) and that the near terminal elimination half-life may be measured in days rather than hours (Cohen et al, 1988).
Likewise, other studies have shown prolonged behavioural effects after one moderate dose of the drug (Cohen, Babb, Campbell and Baldessarini, 1988). In a previous study (Navarro, Miñarro and Simón, 1993) it was observed that 24 hours after administration of haloperidol, this drug still showed antiaggressive effects while immobility effects disappeared. Palabras clave: Haloperidol, Agresión, Conducta No se encontraron diferencias significativas. Cuando el test fue realizado a los 30 minutosĭe la administración, se encontró una disminución del tiempoĭedicado a las conductas ofensivas y a la exploración no social y unĪumento del tiempo de inmovilidad en los animales que recibieron haloperidolĬon respecto a sus controles. Ratones macho, estudiando sus acciones a los 30 minutos, a las 24 y a las 48 Y motores de 0.4 mg/kg de haloperidol sobre la conducta agonística de En este trabajo se intentóĭeterminar la persistencia a través del tiempo de los efectos antiagresivos Previamente con resultados contradictorios.
Los efectos del haloperidol sobre laĬonducta agresiva a las 24 horas de su administración han sido estudiados Key words: Haloperidol, Aggression, Agonistic Behavior,Ĭurso temporal de los efectos del Haloperidol sobre la conductaĪgonística en ratones macho. Differences with similar studies are commented upon.
No significant effects were found 24 or 48 hours after administration. When the test is performed 30 minutes after administration, there is a significant decrease of time allocated to offensive behaviors and nonsocial exploration and a significant increase in time devoted to immobility behavior in the animals that received haloperidol with respect to their controls. This study is an attempt to determine the persistence of the antiaggressive and motor effects of 0.4 mg/kg of haloperidol over time, studying its actions on agonistic behavior in male mice at 30 minutes, at 24 and at 48 hours after administration. The effects of haloperidol on aggressive behaviour 24 hours after administration have been studied previously with contradictory results. Simón.įacultad de Psicología, Universitat de Valéncia. María Asunción Aguilar, Marta Rodríguez-Arias, José Miñarro and Vicente M.
TIME COURSE OF THE EFFECTS OF HALOPERIDOL ON AGONISTIC BEHAVIOUR IN MALE MICE